Study database
Compares against a control group without randomisation. The comparison stays open to systematic differences between groups.
HOHorse
In a crossover comparison in nine evaluable horses, clinical signs and inflammation improved on both forages with no statistical difference between them, while the fall in airway resistance was more pronounced and more sustained on alfalfa pellets than on steamed hay.
HOHorse
Over four weeks, steamed hay prevented neither the rise in airway resistance nor that in the neutrophils, and in this it did not differ from dry hay.
HOHorse
Steaming eliminated typical moulds completely, soaking did not; stored soaked hay showed rising microbial counts again within hours, and both treated hays were taken up more slowly.
HOHorse
Over twelve months, airway smooth muscle fell by around 30% on allergen avoidance as well as on inhaled corticosteroid; inflammation was better controlled on allergen avoidance, function restored faster on the corticosteroid.
HOHorse
Soaking the hay before feeding markedly lowered the mean concentration of respirable dust in the horse's breathing zone, with no additional gain from very long soaking; switching one stable from straw and hay to shavings and haylage also lowered exposure in the neighbouring stall sharing the same air space.
HUHuman
The absorbed fraction fell from 65 to 11 per cent as the single dose increased; on calculation, uptake comprised a saturable component plus around seven per cent of constant absorption, and magnesium from almonds was as available as from magnesium acetate, whereas enteric-coated capsules were markedly worse.
HOHorse
Early balance study on magnesium metabolism in the horse; the paper is indexed without an abstract, and its keywords name the small intestine, intestinal absorption and nutrient requirements. It is cited in the specialist literature as an early basis for later requirement estimates.
HOHorse
A one-hour endotoxin infusion in twelve mares lowered ionised magnesium from 0.53 to 0.43 millimoles per litre and the fraction excreted in the urine from around 37 to 12 per cent: inflammation alone therefore changes the blood value.
HOHorse
In seven horses, a deliberate depletion (ionised calcium 0.48 and magnesium 0.44 millimoles per litre) produced fibrillation potentials and neuromyotonia in every muscle examined, although none of the animals showed clinical signs.
HOHorse
A single intravenous dose in twelve healthy mares raised ionised magnesium 3.7-fold within five minutes, temporarily lowered ionised calcium and altered parathyroid hormone and calcitonin; the paper refers explicitly to its use as a calming agent in competition.
HOHorse
In five healthy, standing and unsedated horses, a magnesium infusion slightly changed heart rate, blood pressure and respiratory rate but left the thresholds for heat, pressure and electrical stimuli unchanged.
HOHorse
In five caecally fistulated horses of around 562 kilograms fed 6.81 kilograms of grass hay dry matter daily, hindgut retention time ranged from 22.2 hours for the liquid phase to 26.3 hours for the coarse particulate phase, with no selection by particle size.
HOHorse
In six caecally fistulated horses in a crossover design, total concentrations of volatile fatty acids were higher in the caecum than in the faeces and higher on lucerne than on bluegrass, while diversity was higher in the faeces than in the caecum.
HOHorse
In four caecally fistulated horses given constant amounts of oats and hay, feeding order alone shifted the timing of the lowest caecal pH from 170 to 280 minutes, and gastric emptying with it, while blood glucose and insulin remained unchanged.
HOHorse
In a Latin square with six caecally fistulated horses, six individual feed ingredients supplemented at the same low amount produced no main effect on pH or volatile fatty acids; interactions with the hour after feeding occurred, and caecal pH stayed within the normal range throughout.
HOHorse
In 19 Bardigiano horses of around 14 months over 129 days, the high-starch ration lowered diversity in the caecum, pelvic flexure and right dorsal colon and raised the proportion of starch-degrading genera associated with acidosis.
HOHorse
In twelve horses, fibre-degrading activity fell two days after an abrupt switch to a high-starch ration, while starch-degrading activity rose; the faecal parameters only reached baseline three to four weeks after the return to the fibre ration.
HOHorse
In the laminitis model induced experimentally with oligofructose, faecal pH fell while lactic acid, histamine and lipopolysaccharide rose in the blood; Lactobacillus and Megasphaera increased, and 137 metabolites changed.
HOHorse
Controlled trial in six horses: mesenchymal stromal cells produced temporarily stronger inflammation and larger lesions between weeks 3 and 6; after 24 weeks there was no clear advantage over serum treatment alone.
RORodent
Experimental test in mouse strains: a design deliberately split across several time points improved reproducibility and the rate of correct findings compared with the conventionally standardised design, though only in around half of the strain comparisons examined.
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